you need to win the pacifier superiority battle before attempting missile strikes on enemy vessels;
forward intercept CSP is by far the most effective posture as usually you can overmatch the incoming strike team;
close in (no more than one flight per vessel) is useful, but is very vulnerable to missile strikes, so needs to be in combination with the forward intercept if done at all;
a tight group of vessels, but not overlapping, gives an effective CSP umbrella (in practice these ought to stack vertically, but the table layout doesn't work like that);
Keep the carriers full or empty when doing CSP/strikes, all actions (e.g. firing/launching) are a ship at a time and better to do it in volume than dribs and drabs;
keep some pacifiers to top up the CSP after an incoming strike;
CSP stays up until it is attacked (or you use it to intercept an incoming strike) so you can probably get away with more than 50% of the available pacifiers in flight, but don't stretch it too far lest you get the CSP stripped off by space superiority missions in advance of the missile strike;
make sure that the CSP that you've placed covers all the vessels in the fleet, and that it can react to an attack on as many as possible (if not all) ships;
remember that the one shot pacifiers can be recycled through the carriers, but take care not to lose carrier flights because you've filled up the carrier with the OSPs;